Pemphigus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus.
|
14646976 |
2003 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with Pemphigus auto-antibodies results in loss of monolayer integrity and altered localization of desmoglein-3, as well as loss of colocalization with flotillin-2.
|
31247885 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
TP did not directly block binding of pemphigus IgG to their target Dsg antigens but prevented PV-IgG-induced inhibition of Dsg3 transinteraction in cell-free (atomic force microscopy) and cell-based (laser tweezer) experiments, indicating stabilization of Dsg3 bonds.
|
19164289 |
2009 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To clone and express EC1-2 and EC3-4 epitopes of PVA (pemphigus vulgaris antigen, desmoglein-3) in order to diagnose pemphigus and study the relationship between epitopes of PVA and anti-PVA antibody.
|
11776114 |
2000 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that this baculovirus product has the proper conformation of the authentic PVA and that its conformation is important in pathogenicity of pemphigus.
|
8040292 |
1994 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations allow us to propose a concept for pemphigus blistering disorders as a "desmosome-remodeling impairment disease" involving a mechanism of Dsg3 nonassembly and depletion from desmosomes through PV immunoglobulin G-activated intracellular signaling events.
|
23257250 |
2013 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it was surprising that mice without desmoglein 3 (the autoantigen in pemphigus vulgaris) not only developed mucous membrane and skin lesions like pemphigus patients, but also developed hair loss.
|
9701552 |
1998 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
|
29740444 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives.
|
10951142 |
2000 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris.
|
31774569 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data indicate that DP phosphorylation at S2849 represents an important mechanism in pemphigus pathogenesis, which, by reversing Ca(2+) insensitivity, promotes Dsg3 depletion.
|
25010392 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion.
|
31178865 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus.
|
31077459 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction.
|
18641320 |
2008 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in Dsg3-knockout (KO) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of PV IgG induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo.
|
17101498 |
2006 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis.
|
17431647 |
2007 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we examined the reactivity of the sera from various types of pemphigus with recombinant proteins of extracellular and intracellular domains of human Dsg1 and Dsg3 by immunoblot analysis.
|
11154866 |
2001 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to verify the pathogenic activity of anti-Desmocollin 3 (DSC3) antibodies, we developed an active disease model of pemphigus expressing anti-DSC3 autoantibodies or anti-DSC3 and anti-DSG3 antibodies.
|
31275323 |
2019 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all patients, the mean of pemphigus disease area index (PDAI) decreased from 20.3 ± 14.1 to 0.4 ± 0.0, whereas the mean Dsg3 value dropped from 157.1 ± 40.6 to 67.0 ± 26.6 after therapy with RTX.
|
31420993 |
2020 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris.
|
18586466 |
2008 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission.
|
29145342 |
2017 |
Pemphigus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ethnic group, age at presentation, initial intercellular antibody titre and initial Dsg 3 antibody levels all had a significant impact on prognosis of pemphigus.
|
24102444 |
2014 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles.
|
12496453 |
2003 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
BEFREE |
BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen.
|
30179341 |
2018 |
Pemphigus
|
0.100 |
Biomarker
|
disease |
LHGDN |
Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity.
|
17428808 |
2007 |